Hepatic metabolic regulation by nuclear factor E4BP4
نویسندگان
چکیده
منابع مشابه
Metabolic Regulation by Nuclear Receptors
Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA e-mail: [email protected] Abstract Nuclear receptors (NRs) are a large family of ligand-dependent transcriptional regulators that control development, reproduction, metabolism, and inflammation. Cognate ligands include fatty acids, bile acids, steroids, vitamins A and D, a...
متن کاملRegulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.
SHP (small heterodimer partner) is an important component of the feedback regulatory cascade, which controls the conversion of cholesterol to bile acids. In order to identify the bona fide molecular targets of SHP, we performed global gene expression profiling combined with chromatin immunoprecipitation assays in transgenic mice constitutively expressing SHP in the liver. We demonstrate that SH...
متن کاملCell type-specific regulation of von Willebrand factor expression by the E4BP4 transcriptional repressor.
Mechanisms of tissue-restricted patterns of von Willebrand factor (VWF) expression involve activators and repressors that limit expression to endothelial cells and megakaryocytes. The relative transcriptional activity of the proximal VWF promoter was assessed in VWF-producing and -nonproducing cells, and promoter activity was highest in endothelial cells followed by megakaryocytes. Only basal V...
متن کاملRegulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha
AIM To uncover the role of hepatocyte nuclear factor 4 alpha (HNF4α) in regulating hepatic expression of microRNAs. METHODS Microarray and real-time PCR were used to determine hepatic expression of microRNAs in young-adult mice lacking Hnf4α expression in liver (Hnf4α-LivKO). Integrative genomics viewer software was used to analyze the public chromatin immunoprecipitation-sequencing datasets ...
متن کاملRegulation of HSulf-1 expression by variant hepatic nuclear factor 1 in ovarian cancer.
We recently identified HSulf-1 as a down-regulated gene in ovarian carcinomas. Our previous analysis indicated that HSulf-1 inactivation in ovarian cancers is partly mediated by loss of heterozygosity and epigenetic silencing. Here, we show that variant hepatic nuclear factor 1 (vHNF1), encoded by transcription factor 2 gene (TCF2, HNF1beta), negatively regulates HSulf-1 expression in ovarian c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2021
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-20-0239